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Formula: C19H21IN2O
Geisbert J
InChi: InChI=1S/C26H30N6O3/c1-4-35-23-15-17(32-13-11-18(33)12-14-32)9-10-20(23)28-26-27-16-22-24(29-26)30(2)21-8-6-5-7-19(21)25(34)31(22)3/h5-10
+1/p-1/t14-
9 μM for epidermal growth factor receptors (EGFR) and 2
CP-465022 (maleate) hrin-β Formula: C19H21IN2OIC50: 25 nM for AMPA receptor mediated currents in rat cortical neurons CP 465022 is an AMPA antagonist. The inhibition of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid (AMPA) receptor has been hypothesized to lead to neuroprotective efficacy after cerebral ischemia on the basis of the activity in ischemia models of a variety of compounds with varying selectivity for AMPA over other glutamate receptor subtypes. In vitro: CP 465022 inhibited
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